5-Ethynyl-2’-deoxyuridine

• CAT Number: R040042
• CAS Number: 61135-33-9
• Molecular Formula: C11H12N2O5
• Molecular Weight: 252.23
• Purity: ≥95%
• Synonyms: EdU; 2’-Deoxy-5-ethynyluridine
• Target: PROTAC Linkers
• Storage: -20°C
• IUPAC Name: 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
• InChIKey: CDEURGJCGCHYFH-DJLDLDEBSA-N
• SMILES: C#CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O

5-Ethynyl-2’-deoxyuridine (Cat No.:R040042) is a thymidine analog used extensively in molecular biology for labeling and tracking DNA synthesis. Its ethynyl group allows for incorporation into newly synthesized DNA strands during cell proliferation. EdU is detected using a copper-catalyzed click chemistry reaction with azide-containing fluorescent dyes, providing a highly specific and efficient method for visualizing DNA replication. This makes EdU a powerful tool for studying cell cycle dynamics, DNA replication, and cell proliferation in various biological and medical research applications, including cancer research and developmental biology.