5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

• CAT Number: R005267
• CAS Number: 97963-62-7
• Molecular Formula: C8H6F2N2OS
• Molecular Weight: 216.21
• Purity: ≥95%
• Synonyms: 5-(Difluoromethoxy)-1,3-dihydro-2H-benzimidazole-2-thione; 5-Difluoromethoxy-2-mercaptobenzimidazole; SKA 47; USP Pantoprazole Related Compound C
• Storage: Store at -20°C
• IUPAC Name: 5-(difluoromethoxy)-1,3-dihydrobenzimidazole-2-thione
• InChI: InChI=1S/C8H6F2N2OS/c9-7(10)13-4-1-2-5-6(3-4)12-8(14)11-5/h1-3,7H,(H2,11,12,14)
• InChIKey: HJMVPNAZPFZXCP-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1OC(F)F)NC(=S)N2

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole（Cat No.:R005267）is a heterocyclic compound featuring a benzimidazole core substituted with a difluoromethoxy group at the 5-position and a mercapto (thiol) group at the 2-position. This multifunctional structure makes it valuable in pharmaceutical and agrochemical research, particularly in the design of bioactive molecules with antiviral, antifungal, or anticancer potential. The difluoromethoxy group enhances lipophilicity and metabolic stability, while the thiol moiety enables further derivatization. Typically a solid, it is soluble in polar organic solvents and is suitable for use in medicinal chemistry and structure–activity relationship (SAR) studies.