5-Chloro Hydrochlorothiazide

• CAT Number: R011397
• CAS Number: 5233-42-1
• Molecular Formula: C7H7Cl2N3O4S2
• Molecular Weight: 332.17
• Purity: ≥95%
• Synonyms: 5,6-Dichloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide
• Storage: -20°C
• IUPAC Name: 5,6-dichloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6}
• InChI: InChI=1S/C7H7Cl2N3O4S2/c8-5-3(17(10,13)14)1-4-7(6(5)9)11-2-12-18(4,15)16/h1,11-12H,2H2,(H2,10,13,14)
• InChIKey: BSNKBIJVLZUERH-UHFFFAOYSA-N
• SMILES: C1NC2=C(C(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl)Cl

5-Chloro Hydrochlorothiazide(CAT: R011397) is a halogenated derivative of hydrochlorothiazide, a thiazide-class diuretic commonly used to treat hypertension and fluid retention. The introduction of a chlorine atom at the 5-position may influence the compound’s pharmacokinetic and pharmacodynamic properties, making it significant in impurity profiling, structural analog development, and SAR (structure-activity relationship) studies. It is typically encountered as an intermediate or process-related impurity during the synthesis of hydrochlorothiazide and is important for regulatory compliance and quality control in pharmaceutical manufacturing.