5-Bromo-2-fluorophenylboronic Acid

• CAT Number: R042799
• CAS Number: 112204-57-6
• Molecular Formula: C6H5BBrFO2
• Molecular Weight: 218.82
• Purity: ≥95%
• Synonyms: 5-Bromo-2-fluorobenzeneboronic Acid; B-(5-Bromo-2-fluorophenyl)boronic Acid
• Storage: -20°C
• IUPAC Name: (5-bromo-2-fluorophenyl)boronic acid
• InChI: InChI=1S/C6H5BBrFO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,10-11H
• InChIKey: IGBDPRKNAFOOGY-UHFFFAOYSA-N
• SMILES: B(C1=C(C=CC(=C1)Br)F)(O)O

5-Bromo-2-fluorophenylboronic acid(CAT: R042799) is a halogenated arylboronic acid bearing a bromine atom at the 5-position and a fluorine atom at the 2-position on the phenyl ring, along with a boronic acid functional group. This compound is a valuable reagent in Suzuki–Miyaura cross-coupling reactions, enabling the construction of highly functionalized biaryl and heteroaryl structures. The dual halogen substitution provides opportunities for orthogonal functionalization and sequential coupling strategies, making it especially useful in the synthesis of pharmaceutical intermediates, materials, and complex organic frameworks.