For research use only. Not for therapeutic Use.
5-Azidomethyl-uridine (Cat No.: I042576) is a modified nucleoside featuring an azidomethyl group at the 5-position of the uracil base. This structural modification introduces a reactive azide moiety, enabling bioorthogonal conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (click chemistry). It is commonly used for labeling, tracking, and functionalizing RNA molecules in biochemical and cellular studies. 5-Azidomethyl-uridine is valuable in synthetic biology, nucleic acid therapeutics, and molecular probe development, allowing site-specific modifications and exploration of RNA structure, dynamics, and interactions.
| CAS Number | 24751-67-5 |
| Synonyms | 5-(azidomethyl)-1-[(2R,3S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Molecular Formula | C10H13N5O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H13N5O6/c11-14-12-1-4-2-15(10(20)13-8(4)19)9-7(18)6(17)5(3-16)21-9/h2,5-7,9,16-18H,1,3H2,(H,13,19,20)/t5-,6?,7+,9-/m1/s1 |
| InChIKey | ZAFBFGDCEFQDFD-AOXOCZDOSA-N |
| SMILES | C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)CN=[N+]=[N-] |
| Reference | [1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
