4',5'-Didehydro-5'-deoxyuridine

• CAT Number: I041265
• CAS Number: 14365-63-0
• Molecular Formula: C9H10N2O5
• Molecular Weight: 226.19
• Purity: ≥95%
• Synonyms: 1-[(2R,3S)-3,4-dihydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C9H10N2O5/c1-4-6(13)7(14)8(16-4)11-3-2-5(12)10-9(11)15/h2-3,6-8,13-14H,1H2,(H,10,12,15)/t6?,7-,8+/m0/s1
• InChIKey: WMIBCMZGMYGWHB-ZHFSPANRSA-N
• SMILES: C=C1C(C(C(O1)N2C=CC(=O)NC2=O)O)O

4′,5′-Didehydro-5′-deoxyuridine (Cat No.: I041265) is a modified uridine analog featuring a double bond between the 4′ and 5′ positions of the sugar ring and lacking the 5′-hydroxyl group. This structural alteration disrupts normal nucleoside function, making it a useful compound in biochemical and pharmacological research. It is studied for its potential to inhibit nucleic acid synthesis and its resistance to enzymatic degradation. The compound is valuable in exploring nucleotide analog mechanisms, antiviral strategies, and as a probe in nucleoside metabolism and enzyme activity assays.

Reference

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
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