4-(Trifluoromethyl)phenylboronic Acid

• CAT Number: R026310
• CAS Number: 128796-39-4
• Molecular Formula: C7H6BF3O2
• Molecular Weight: 189.93
• Purity: ≥95%
• Synonyms: [4-(Trifluoromethyl)phenyl]boronic Acid; 4-(Trifluoromethyl)benzeneboronic Acid; [p-(Trifluoromethyl)phenyl]boronic Acid; α,α,α-Trifluoro-p-tolylboronic Acid
• Storage: Store at RT
• IUPAC Name: [4-(trifluoromethyl)phenyl]boronic acid
• InChI: InChI=1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H
• InChIKey: ALMFIOZYDASRRC-UHFFFAOYSA-N
• SMILES: B(C1=CC=C(C=C1)C(F)(F)F)(O)O

4-(Trifluoromethyl)phenylboronic acid (Cat No.: R026310) is an arylboronic acid featuring a trifluoromethyl group at the para position of the phenyl ring. Widely used in Suzuki–Miyaura cross-coupling reactions, it serves as a valuable building block for constructing biaryl compounds, agrochemicals, and pharmaceuticals. The trifluoromethyl group enhances the molecule’s lipophilicity, metabolic stability, and bioactivity, making it particularly attractive for medicinal chemistry. Its reactivity and electron-withdrawing character also influence reaction selectivity, aiding in the development of fluorinated compounds with diverse functional applications.

Reference

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