4-(Trifluoromethyl)-1H-indazole

• CAT Number: L035294
• CAS Number: 1000339-98-9
• Molecular Formula: C8H5F3N2
• Molecular Weight: 186.13
• Purity: ≥95%
• IUPAC Name: 4-(trifluoromethyl)-1H-indazole
• InChI: InChI=1S/C8H5F3N2/c9-8(10,11)6-2-1-3-7-5(6)4-12-13-7/h1-4H,(H,12,13)
• InChIKey: KCWIWQGNCLKDJZ-UHFFFAOYSA-N
• SMILES: C1=CC(=C2C=NNC2=C1)C(F)(F)F

4-(Trifluoromethyl)-1H-indazole（Cat No.:L035294）is a fluorinated heterocyclic compound featuring an indazole core substituted with a trifluoromethyl group at the 4-position. This structural motif imparts significant lipophilicity, metabolic stability, and electronic effects, making it a valuable scaffold in medicinal chemistry. The indazole ring system is known for its biological relevance, particularly in developing kinase inhibitors, anti-inflammatory agents, and anticancer drugs. The trifluoromethyl group enhances membrane permeability and receptor binding affinity. As such, this compound is frequently employed in drug discovery and chemical biology as a precursor or pharmacophore in lead optimization efforts.