4-Thiouridine

  • CAT Number: R053766
  • CAS Number: 13957-31-8
  • Molecular Formula: C9H12N2O5S
  • Molecular Weight: 260.264
  • Purity: ≥95%
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4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

Catalog Number R053766
CAS Number 13957-31-8
Molecular Formula

C9H12N2O5S

Purity 95%
Storage -20°C
IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
InChI InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
InChIKey ZLOIGESWDJYCTF-XVFCMESISA-N
SMILES C1=CN(C(=O)NC1=S)C2C(C(C(O2)CO)O)O

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