For research use only. Not for therapeutic Use.
(4-NH₂)-Exatecan（Cat No.:I045139）is a synthetic derivative of exatecan, a highly potent topoisomerase I inhibitor used in the development of antibody–drug conjugates (ADCs). The 4-amino substitution enhances conjugation compatibility and allows for site-specific attachment via cleavable linkers. Once released inside target cells, (4-NH₂)-Exatecan binds to the topoisomerase I-DNA complex, preventing DNA re-ligation and inducing lethal DNA damage. It has shown strong cytotoxic activity against a range of tumor types. Supplied for advanced research in targeted cancer therapies, ADC payload optimization, and DNA damage-based chemotherapeutic strategies.
| CAS Number | 2495742-21-5 |
| Synonyms | (10S)-19-amino-10-ethyl-10-hydroxy-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16(24),17,19-heptaene-5,9-dione |
| Molecular Formula | C23H21N3O4 |
| Purity | ≥95% |
| IUPAC Name | (10S)-19-amino-10-ethyl-10-hydroxy-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16(24),17,19-heptaene-5,9-dione |
| InChI | InChI=1S/C23H21N3O4/c1-2-23(29)15-8-18-20-13(9-26(18)21(27)14(15)10-30-22(23)28)11-4-3-5-12-16(24)6-7-17(25-20)19(11)12/h6-8,29H,2-5,9-10,24H2,1H3/t23-/m0/s1 |
| InChIKey | VMSFUDYSPMXQSY-QHCPKHFHSA-N |
| SMILES | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5CCCC6=C(C=CC(=C56)N=C4C3=C2)N)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
