4-Hydroxytamoxifen

• CAT Number: I004556
• CAS Number: 68047-06-3
• Molecular Formula: C26H29NO2
• Molecular Weight: 387.52
• Purity: ≥95%
• Synonyms: 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol
• IUPAC Name: 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
• InChI: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
• InChIKey: TXUZVZSFRXZGTL-QPLCGJKRSA-N
• SMILES: CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3

4-Hydroxytamoxifen（Cat No.:I004556）is a potent active metabolite of tamoxifen, widely used in breast cancer research as a selective estrogen receptor modulator (SERM). It binds estrogen receptors (ER) with high affinity, exerting antagonistic effects in breast tissue while maintaining partial agonist activity in other tissues. 4-Hydroxytamoxifen is commonly employed in studies involving estrogen signaling, hormone-dependent cancers, and gene regulation. It is also essential in inducible Cre-loxP systems, where it activates Cre recombinase fused to a modified estrogen receptor. Its dual activity makes it a versatile tool in molecular and cancer biology.