4-Epi Minocycline

• CAT Number: R045528
• CAS Number: 43168-51-0
• Molecular Formula: C23H27N3O7
• Molecular Weight: 457.48
• Purity: ≥95%
• Synonyms: [4R-(4α,4aβ,5aβ,12aβ)]-4,7-bis(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 4-Epiminocycline; 4-epi-Minocycline; Epiminocycline
• Storage: Store at RT
• IUPAC Name: (4R,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
• InChI: InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17+,23-/m0/s1
• InChIKey: FFTVPQUHLQBXQZ-MJPDVNATSA-N
• SMILES: CN(C)[C@@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C

4-Epi-minocycline（Cat No.:R045528）is an epimer of the tetracycline antibiotic minocycline, differing by the stereochemistry at the 4-position of the molecule. This structural change can alter its biological activity, stability, and pharmacokinetics. 4-Epi-minocycline may arise as a degradation product or metabolite and is often monitored in pharmaceutical formulations for quality control purposes. While it retains some antimicrobial properties, it is generally less potent than minocycline and may exhibit different toxicity or resistance profiles. Understanding its presence and behavior is important in drug stability studies and in the development of next-generation tetracycline derivatives.