4-Chloro-5-fluoropyrimidine

• CAT Number: L013821
• CAS Number: 347418-42-2
• Molecular Formula: C4H2ClFN2
• Molecular Weight: 132.52
• Purity: ≥95%
• IUPAC Name: 4-chloro-5-fluoropyrimidine
• InChI: InChI=1S/C4H2ClFN2/c5-4-3(6)1-7-2-8-4/h1-2H
• InChIKey: APSSAJKZELMQNM-UHFFFAOYSA-N

4-Chloro-5-fluoropyrimidine(CAT: L013821) is a halogenated pyrimidine derivative featuring chlorine and fluorine substitutions at the 4- and 5-positions of the heterocyclic ring. This electron-deficient aromatic scaffold is highly reactive in nucleophilic aromatic substitution (SNAr) reactions, making it an ideal intermediate for the synthesis of diverse pyrimidine-based compounds. It is widely used in medicinal chemistry for developing kinase inhibitors, antiviral agents, and anticancer therapeutics. The compound’s dual halogenation allows for regioselective functionalization, supporting structure–activity relationship (SAR) studies.