4-Chloro-3-(trifluoromethyl)phenyl Isocyanate

• CAT Number: R045359
• CAS Number: 327-78-6
• Molecular Formula: C8H3ClF3NO
• Molecular Weight: 221.56
• Purity: ≥95%
• Synonyms: 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene; Isocyanic Acid 4-Chloro-α,α,α-trifluoro-m-tolyl Ester; 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene; 3-Trifluoromethyl-4-chlorophenyl Isocyanate; 4-Chloro-1-isocyanato-3-trifluoromethylbenzene; 4-
• Storage: -20°C
• IUPAC Name: 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene
• InChI: InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H
• InChIKey: NBJZEUQTGLSUOB-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1N=C=O)C(F)(F)F)Cl

4-Chloro-3-(trifluoromethyl)phenyl isocyanate（Cat No.:R045359）is an aromatic isocyanate featuring a chloro group at the para position and a trifluoromethyl group at the meta position relative to the isocyanate functional group. This compound is a reactive intermediate commonly used in the synthesis of ureas, carbamates, and other nitrogen-containing heterocycles. Its electron-withdrawing substituents enhance the reactivity of the isocyanate group, making it valuable in pharmaceutical, agrochemical, and polymer research. The presence of fluorine improves metabolic stability and lipophilicity, often contributing to improved pharmacokinetic profiles in drug development applications.