<p style=/line-height:25px/>4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.<br>Target: Potassium Channel<br>4-Aminopyridine(4AP) is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. 4AP strongly potentiates transmitter release from the unmyelinated terminals of rat motor nerves, and the possibility arose that demyelinated axon membrane, which can conduct impulses continuously like an unmyelinated fibre, might further resemble its unmyelinated terminals by responding to 4AP. In testing this hypothesis [1]. 4-AP blocked channels from the cytosolic face. 4-AP can both enhance and block Kv1.5 current and suggest that 4-AP can bind with different affinities to more than one site on Kv1.5 channels [2].<br></p>
| Catalog Number | I003792 |
| CAS Number | 504-24-5 |
| Molecular Formula | C5H6N2 |
| Purity | 95% |
| Target | Potassium Channel |
| Solubility | water：50 mg/ml； 100 mM in DMSO ； |
| Storage | Store at -20C |
| InChIKey | NUKYPUAOHBNCPY-UHFFFAOYSA-N |
| Reference | </br>1:KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment. Hernandez-Ojeda M, Ureña-Guerrero ME, Gutierrez-Barajas PE, Cardenas-Castillo JA, Camins A, Beas-Zarate C.J Biomed Sci. 2017 May 9;24(1):27. doi: 10.1186/s12929-017-0335-y. PMID: 28486943 Free PMC Article</br>2:Synthesis, crystal structure and study of the crystal packing in the complex bis(4-aminopyridine-κN<sup>1</sup>)dichloridocobalt(II). Sanchez Montilva OC, Movilla F, Rodriguez MG, Di Salvo F.Acta Crystallogr C Struct Chem. 2017 May 1;73(Pt 5):399-406. doi: 10.1107/S2053229617004880. Epub 2017 Apr 21. PMID: 28469066 </br>3:Enantiodivergent Steglich rearrangement of <i>O</i>-carboxylazlactones catalyzed by a chirality switchable helicene containing a 4-aminopyridine unit. Chen CT, Tsai CC, Tsou PK, Huang GT, Yu CH.Chem Sci. 2017 Jan 1;8(1):524-529. doi: 10.1039/c6sc02646j. Epub 2016 Aug 25. PMID: 28451199 Free PMC Article</br>4:Effect of 4-Aminopyridine on Genioglossus Muscle Activity during Sleep in Healthy Adults. Taranto-Montemurro L, Sands SA, Azarbarzin A, Marques M, de Melo CM, Edwards BA, Eckert DJ, Messineo L, White DP, Wellman A.Ann Am Thorac Soc. 2017 Apr 7. doi: 10.1513/AnnalsATS.201701-006OC. [Epub ahead of print] PMID: 28387543 </br>5:4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats. Moriguchi K, Miyamoto K, Kusunoki S.J Neuroimmunol. 2017 Apr 15;305:72-74. doi: 10.1016/j.jneuroim.2017.01.023. Epub 2017 Feb 2. PMID: 28284349 </br>6:Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. Sanya EO, Soladoye AO, Desalu OO, Kolo PM, Olatunji LA, Olarinoye JK.Niger J Physiol Sci. 2017 Mar 6;31(2):115-119. PMID: 28262846 </br>7:Clinically Relevant Levels of 4-Aminopyridine Strengthen Physiological Responses in Intact Motor Circuits in Rats, Especially After Pyramidal Tract Injury. Sindhurakar A, Mishra AM, Gupta D, Iaci JF, Parry TJ, Carmel JB.Neurorehabil Neural Repair. 2017 Apr;31(4):387-396. doi: 10.1177/1545968316688800. Epub 2017 Jan 20. PMID: 28107804 </br>8:Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats. Shiha AA, de la Rosa RF, Delgado M, Pozo MA, García-García L.CNS Neurol Disord Drug Targets. 2016 Jul 20. [Epub ahead of print] PMID: 27989232 </br>9:4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury. Tseng KC, Li H, Clark A, Sundem L, Zuscik M, Noble M, Elfar J.EMBO Mol Med. 2016 Dec 1;8(12):1409-1420. doi: 10.15252/emmm.201506035. Print 2016 Dec. PMID: 27861125 Free PMC Article</br>10:Tetraethylammonium and 4-aminopyridine block calcium-dependent chloride current in rat cerebellum Purkinje cells. Zamoyski VL, Vikhareva EA, Grigoriev VV, Bachurin SO.Dokl Biochem Biophys. 2016 Sep;470(1):332-334. Epub 2016 Nov 6. PMID: 27817032 |
