4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

• CAT Number: L011774
• CAS Number: 763111-47-3
• Molecular Formula: C20H19FN4O2
• Molecular Weight: 366.41
• Purity: ≥95%
• Target: Cell Cycle/DNA Damage
• IUPAC Name: 4-[[4-fluoro-3-(piperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
• InChI: InChI=1S/C20H19FN4O2/c21-17-6-5-13(11-16(17)20(27)25-9-7-22-8-10-25)12-18-14-3-1-2-4-15(14)19(26)24-23-18/h1-6,11,22H,7-10,12H2,(H,24,26)
• InChIKey: MFFUYEOGICAKCK-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F

4-(4-Fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one(CAT: L011774) is a complex heterocyclic compound featuring a phthalazinone core linked to a fluorinated benzyl group with a piperazine-1-carbonyl substituent. This structure is characteristic of kinase-targeting scaffolds and serves as a valuable intermediate in oncology drug discovery, particularly in the development of VEGFR, PDGFR, or PARP inhibitors. The combination of pharmacophoric motifs—including the piperazine ring and fluorinated aromatic moiety—enhances receptor binding affinity, solubility, and metabolic stability. It is commonly used in medicinal chemistry programs for structure–activity relationship (SAR) studies and the synthesis of novel small-molecule inhibitors with therapeutic potential in cancer and inflammatory diseases.