For research use only. Not for therapeutic Use.
(3S,4S)-Tivantinib(CAT: I040452) is a potent and enantiomerically defined small-molecule inhibitor that selectively targets the receptor tyrosine kinase c-MET, a key driver in tumor cell proliferation, survival, and metastasis. In addition to c-MET inhibition, (3S,4S)-Tivantinib also modulates two novel targets—GSK3α and GSK3β—critical regulators of signaling pathways implicated in non-small cell lung cancer (NSCLC). This dual-target activity enhances its therapeutic potential, particularly in overcoming resistance mechanisms in c-MET-driven cancers. (3S,4S)-Tivantinib is a valuable tool for oncology research, supporting studies on signal transduction, targeted therapy development, and mechanistic exploration of GSK3-associated tumor biology.
| CAS Number | 905854-03-7 |
| Synonyms | (3S,4S)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione |
| Molecular Formula | C23H19N3O2 |
| Purity | ≥95% |
| IUPAC Name | (3S,4S)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione |
| InChI | InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m1/s1 |
| InChIKey | UCEQXRCJXIVODC-WOJBJXKFSA-N |
| SMILES | C1CC2=C3C(=CC=C2)C(=CN3C1)C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
