3PO

3PO

  • CAT Number: I000057
  • CAS Number: 13309-08-5
  • Molecular Formula: C13H10N2O
  • Molecular Weight: 210.23
  • Purity: ≥95%
Inquiry Now

3PO (Cat.No: I000057) is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer.

Catalog Number I000057
CAS Number 13309-08-5
Molecular Formula

C13H10N2O

Purity 95%
Target PFKFB3 inhibitor
Solubility Soluble in DMSO, not in water
Storage Store at -20°C
IUPAC Name (E)-3-pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one
InChI InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
InChIKey UOWGYMNWMDNSTL-ONEGZZNKSA-N
SMILES C1=CC(=CN=C1)C=CC(=O)C2=CC=NC=C2
Reference

</br>1:Impact of the cellular prion protein on amyloid-β and 3PO-tau processing. Schmitz M, Wulf K, Signore SC, Schulz-Schaeffer WJ, Kermer P, Bähr M, Wouters FS, Zafar S, Zerr I.J Alzheimers Dis. 2014;38(3):551-65. doi: 10.3233/JAD-130566. PMID: 24028865 </br>2:3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Medina-Kauwe LK, Kasahara N, Kedes L.Gene Ther. 2001 May;8(10):795-803. PMID: 11420644 Free Article</br>3:Measurement of the lifetime of the 1s2p 3Po state in Be Scholl TJ, Rosner SD, Holt RA.Phys Rev A. 1996 Apr;53(4):2130-2134. No abstract available. PMID: 9913118 </br>4:Electron affinities of 1s22s2p 3Po and 1s22p2 3P of beryllium. Hsu JJ, Chung KT.Phys Rev A. 1995 Aug;52(2):R898-R901. No abstract available. PMID: 9912431 </br>5:Doubly excited 3Po resonance states of He below the N=2 and N=3 He+ thresholds. Ho YK.Phys Rev A. 1993 Nov;48(5):3598-3605. No abstract available. PMID: 9910025 </br>6:CEO expectation: the Star Wars materiel manager of the 1990s, or C-3PO as role model. Zenty TF, Olson MR.Hosp Mater Manage Q. 1993 May;14(4):15-20. PMID: 10125274 </br>7:Multichannel photoionization of metastable He(2 (3)Se): A complete study of the 3Po resonances between the N=2 and 3 thresholds. Sánchez I I, Martin F.Phys Rev A. 1993 Mar;47(3):1878-1886. No abstract available. PMID: 9909142 </br>8:1,3Po resonance states in positronium ions. Ho YK, Bhatia AK.Phys Rev A. 1991 Sep 1;44(5):2890-2894. No abstract available. PMID: 9906287

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!