3-O-Methyldopa

• CAT Number: I009232
• CAS Number: 300-48-1
• Molecular Formula: C10H13NO4
• Molecular Weight: 211.21
• Purity: ≥95%
• Synonyms: (2S)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid
• InChI: InChI=1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)/t7-/m0/s1
• InChIKey: PFDUUKDQEHURQC-ZETCQYMHSA-N
• SMILES: COC1=C(C=CC(=C1)CC(C(=O)O)N)O

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

Reference

[1]. Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52.
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