3-Methylhistamine dihydrochloride

• CAT Number: R004360
• CAS Number: 36475-47-5
• Molecular Formula: C6H13Cl2N3
• Molecular Weight: 198.09
• Purity: ≥95%
• Synonyms: 2-(3-methylimidazol-4-yl)ethanamine;dihydrochloride
• InChI: InChI=1S/C6H11N3.2ClH/c1-9-5-8-4-6(9)2-3-7;;/h4-5H,2-3,7H2,1H3;2*1H
• InChIKey: KWEIZIDNCJBKIY-UHFFFAOYSA-N
• SMILES: CN1C=NC=C1CCN.Cl.Cl

3-Methylhistamine dihydrochloride (Cat No.: R004360) is a biologically relevant metabolite of histamine, formed through the methylation of the imidazole ring at the 3-position. It is commonly used as a biochemical marker in studies of histamine metabolism and mast cell activation. As a stable salt form, the dihydrochloride enhances its solubility and handling in laboratory applications. 3-Methylhistamine is of interest in allergy, inflammation, and neurological research, helping to elucidate histamine-related signaling pathways and enzymatic activity involving histamine N-methyltransferase.

Reference

[1]. Schayer RW, et al. Methyl derivatives of histamine; interaction with histamine metabolism. Agents Actions. 1975;5(3):231-235.
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[2]. Gill EL, et al. Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry Metabolomics and Lipidomics Study of Stool from Transgenic Parkinson’s Disease Mice Following Immunotherapy. J Proteome Res. 2020;19(1):424-431.
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