3-Mercaptopicolinic Acid Hydrochloride

• CAT Number: R000188
• CAS Number: 320386-54-7
• Molecular Formula: C6H6ClNO2S
• Molecular Weight: 191.63
• Purity: ≥95%
• Synonyms: 3-Mercapto-2-pyridinecarboxylic Acid Hydrochloride
• Target: PEPCK
• Storage: -20°C
• IUPAC Name: 3-sulfanylpyridine-2-carboxylic acid;hydrochloride
• InChI: InChI=1S/C6H5NO2S.ClH/c8-6(9)5-4(10)2-1-3-7-5;/h1-3,10H,(H,8,9);1H
• InChIKey: DYGYEUUVNLEHJP-UHFFFAOYSA-N
• SMILES: C1=CC(=C(N=C1)C(=O)O)S.Cl

3-Mercaptopicolinic acid hydrochloride(CAT: R000188) is a thiol-containing pyridine derivative presented as its hydrochloride salt for enhanced stability and handling. Known for its potent inhibitory activity against phosphoenolpyruvate carboxykinase (PEPCK), it is widely used in metabolic research to study gluconeogenesis and related biochemical pathways. By blocking PEPCK, it helps elucidate mechanisms of glucose production in the liver and kidney, supporting investigations into diabetes, obesity, and metabolic syndrome. Its unique combination of a pyridine ring and thiol functionality also makes it a useful scaffold in medicinal chemistry for developing enzyme inhibitors and probing metabolic regulation at the molecular level.