For research use only. Not for therapeutic Use.
3-Hydroxy Midostaurin（Cat No.:I006049）is an active metabolite of midostaurin, a multi-targeted kinase inhibitor used in cancer research. Like its parent compound, it inhibits multiple kinases including FLT3, KIT, and protein kinase C (PKC), which are critical drivers of oncogenic signaling, cell proliferation, and survival. The hydroxylated metabolite contributes to the overall therapeutic activity of midostaurin, particularly in acute myeloid leukemia (AML) and systemic mastocytosis. Studying 3-Hydroxy Midostaurin provides insights into drug metabolism, pharmacodynamics, and efficacy, making it valuable for oncology drug development and pharmacological research.
| CAS Number | 179237-49-1 |
| Synonyms | N-[(2S,3R,4R,6R)-18-hydroxy-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide |
| Molecular Formula | C35H30N4O5 |
| Purity | ≥95% |
| IUPAC Name | N-[(2S,3R,4R,6R)-18-hydroxy-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide |
| InChI | InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33?,35+/m1/s1 |
| InChIKey | ZZSBPGIGIUFJRA-YMZPHHGTSA-N |
| SMILES | C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)N(C)C(=O)C9=CC=CC=C9)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
