(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol(Contain up to 15percent ∆25 isomer)

• CAT Number: R055937
• CAS Number: 64284-64-6
• Molecular Formula: C29H46O
• Molecular Weight: 410.686
• Purity: ≥95%
• Synonyms: 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol; FF-MAS; Follicular Fluid Meiosis-activating Sterol
• Storage: Store at -20C
• IUPAC Name: (3S,5R,10S,13R,17R)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol
• InChI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1
• InChIKey: LFQXEZVYNCBVDO-PBJLWWPKSA-N
• SMILES: CC(CCC=C(C)C)C1CC=C2C1(CCC3=C2CCC4C3(CCC(C4(C)C)O)C)C

(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol (CAS 64284-64-6) is a follicular fluid meiosis-activating sterol (FF-MAS); a factor present in the pre-ovulatory follicle during the time of oocyte maturation. (3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol has been shown to protect young oocytes from precocious chromatid separation as well as protecting aged oocytes from predivision during maturation.

Reference

1.Cao, Xiumei, et al. "Meiosis-activating sterol synthesis in rat preovulatory follicle: is it involved in resumption of meiosis?." Biology of reproduction 71.6 (2004): 1807-1812.
2.Cukurcam, S., et al. "Influence of follicular fluid meiosis-activating sterol on aneuploidy rate and precocious chromatid segregation in aged mouse oocytes." Human Reproduction 22.3 (2007): 815-828.