(2S,4S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid

• CAT Number: L022456
• CAS Number: 203866-19-7
• Molecular Formula: C20H18FNO4
• Molecular Weight: 355.40
• Purity: ≥95%
• IUPAC Name: (2S,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C20H18FNO4/c21-12-9-18(19(23)24)22(10-12)20(25)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18H,9-11H2,(H,23,24)/t12-,18-/m0/s1
• InChIKey: CJEQUGHYFSTTQT-SGTLLEGYSA-N
• SMILES: C1[C@@H](CN([C@@H]1C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)F

(2S,4S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid（Cat No.:L022456）is a fluorinated, chiral pyrrolidine derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. It serves as a non-natural amino acid building block in solid-phase peptide synthesis (SPPS). The fluorine atom at the 4-position introduces electronic and steric effects that can influence peptide conformation, stability, and biological activity. Its (2S,4S) stereochemistry ensures compatibility with stereospecific peptide assembly. Widely used in medicinal chemistry and structure–activity relationship (SAR) studies, this compound is essential for designing fluorinated peptides and peptidomimetics with enhanced pharmacokinetic and therapeutic properties.