(2S,3R)-Voruciclib hydrochloride

• CAT Number: I046103
• CAS Number: 2920469-94-7
• Molecular Formula: C22H20Cl2F3NO5
• Molecular Weight: 506.30
• Purity: ≥95%
• Synonyms: 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2S,3R)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochloride

(2S,3R)-Voruciclib hydrochloride（Cat No.:I046103）is a potent, selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, with activity against CDK4, CDK6, and CDK1. By targeting transcriptional regulation and cell cycle progression, it suppresses oncogenic signaling pathways and promotes apoptosis in malignant cells. This compound has shown promise in preclinical cancer models, including hematological malignancies and solid tumors, where CDK-driven proliferation is critical. With high oral bioavailability and defined stereochemistry, (2S,3R)-Voruciclib hydrochloride is a valuable research tool for cancer and cell cycle regulation studies.