For research use only. Not for therapeutic Use.
(2R,3R)-Firazorexton(CAT: I040631) is a stereochemically defined, orally active small-molecule agonist of the orexin-2 receptor (OX2R), a G protein-coupled receptor involved in regulating wakefulness, arousal, and sleep-wake cycles. The (2R,3R) configuration of Firazorexton contributes to its high potency, selectivity, and central nervous system (CNS) activity. This compound is being studied for its potential in treating narcolepsy, idiopathic hypersomnia, and other sleep-related disorders by promoting wakefulness through targeted OX2R activation. It is a valuable tool for neuroscience and pharmacological research focused on orexin signaling pathways and sleep regulation.
| CAS Number | 2692692-00-3 |
| Synonyms | N-[(2R,3R)-2-[[3-(3,5-difluorophenyl)-2-fluorophenyl]methyl]-1-(2-hydroxy-2-methylpropanoyl)pyrrolidin-3-yl]methanesulfonamide |
| Molecular Formula | C22H25F3N2O4S |
| Purity | ≥95% |
| IUPAC Name | N-[(2R,3R)-2-[[3-(3,5-difluorophenyl)-2-fluorophenyl]methyl]-1-(2-hydroxy-2-methylpropanoyl)pyrrolidin-3-yl]methanesulfonamide |
| InChI | InChI=1S/C22H25F3N2O4S/c1-22(2,29)21(28)27-8-7-18(26-32(3,30)31)19(27)11-13-5-4-6-17(20(13)25)14-9-15(23)12-16(24)10-14/h4-6,9-10,12,18-19,26,29H,7-8,11H2,1-3H3/t18-,19-/m1/s1 |
| InChIKey | VOSAWOSMGPKQEQ-RTBURBONSA-N |
| SMILES | CC(C)(C(=O)N1CCC(C1CC2=C(C(=CC=C2)C3=CC(=CC(=C3)F)F)F)NS(=O)(=O)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
