2,6-Difluorobenzenesulfonyl Chloride

• CAT Number: R060342
• CAS Number: 60230-36-6
• Molecular Formula: C6H3ClF2O2S
• Molecular Weight: 212.60
• Purity: ≥95%
• Synonyms: 2,6-Difluorobenzene-1-sulfonyl Chloride
• Storage: Store at RT
• IUPAC Name: 2,6-difluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H3ClF2O2S/c7-12(10,11)6-4(8)2-1-3-5(6)9/h1-3H
• InChIKey: QXWAUQMMMIMLTO-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)F)S(=O)(=O)Cl)F

2,6-Difluorobenzenesulfonyl chloride（Cat No.:R060342）is an electrophilic aromatic sulfonyl chloride bearing fluorine atoms at the 2 and 6 positions of the benzene ring. This compound is a valuable reagent in organic synthesis, especially for the preparation of sulfonamides, sulfonate esters, and other sulfonyl derivatives. The electron-withdrawing fluorine atoms enhance the reactivity of the sulfonyl chloride group, promoting efficient coupling with nucleophiles such as amines and alcohols. It is widely used in medicinal chemistry, agrochemical synthesis, and materials science for introducing fluorinated sulfonyl groups that influence biological activity, solubility, and metabolic stability.