2,4-Dichloro-5-trifluoromethylpyrimidine

• CAT Number: R027061
• CAS Number: 3932-97-6
• Molecular Formula: C5HCl2F3N2
• Molecular Weight: 216.97
• Purity: ≥95%
• Synonyms: 2,6-Dichloro-5-trifluoromethylpyrimidine; 5-Trifluoromethyl-2,4-dichloropyrimidine
• Storage: Store at -20°C
• IUPAC Name: 2,4-dichloro-5-(trifluoromethyl)pyrimidine
• InChI: InChI=1S/C5HCl2F3N2/c6-3-2(5(8,9)10)1-11-4(7)12-3/h1H
• InChIKey: IDRUEHMBFUJKAK-UHFFFAOYSA-N
• SMILES: C1=C(C(=NC(=N1)Cl)Cl)C(F)(F)F

2,4-Dichloro-5-trifluoromethylpyrimidine(CAT: R027061) is a halogenated heteroaromatic compound with the molecular formula C₅HCl₂F₃N₂. It features a pyrimidine ring substituted with chlorine atoms at the 2- and 4-positions and a trifluoromethyl group at the 5-position. This combination of electron-withdrawing substituents makes the molecule highly electrophilic, enabling it to serve as a reactive intermediate in nucleophilic aromatic substitution (SNAr) reactions. It is widely employed in the synthesis of pharmaceuticals, agrochemicals, and specialty heterocycles, where the pyrimidine scaffold is a key bioactive motif. Its strong reactivity and ability to introduce trifluoromethyl functionality make it valuable in medicinal chemistry and fine chemical research.