2’,3’-Di-O-acetyl-5’-deoxy-5-fluoro-N4-(pentoxycarbonxyl)cytidine

• CAT Number: R003932
• CAS Number: 162204-20-8
• Molecular Formula: C19H26FN3O8
• Molecular Weight: 443.43
• Purity: ≥95%
• Synonyms: 5’-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2’,3’-Diacetate; [1-(2,3-Di-O-acetyl-5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]carbamic Acid Pentyl Ester; 2’,3’-Di-O-acetylcapecitabine
• Storage: Store at RT
• IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-5-[5-fluoro-2-oxo-4-(pentoxycarbonylamino)pyrimidin-1-yl]-2-methyloxolan-3-yl] acetate
• InChI: InChI=1S/C19H26FN3O8/c1-5-6-7-8-28-19(27)22-16-13(20)9-23(18(26)21-16)17-15(31-12(4)25)14(10(2)29-17)30-11(3)24/h9-10,14-15,17H,5-8H2,1-4H3,(H,21,22,26,27)/t10-,14-,15-,17-/m1/s1
• InChIKey: WMJHGZFQHPCWQZ-GWBBYGMBSA-N
• SMILES: CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)OC(=O)C)OC(=O)C

2’,3’-Di-O-acetyl-5’-deoxy-5-fluoro-N4-(pentoxycarbonyl)cytidine (Cat No.: R003932) is a protected fluorinated cytidine analog used as a precursor in the synthesis of chemotherapeutic agents, particularly prodrugs of 5-fluorocytidine. The acetyl groups on the 2’ and 3’ hydroxyls improve lipophilicity and cellular uptake, while the N4-pentoxycarbonyl modification enhances membrane permeability and metabolic stability. The 5-fluoro substitution is crucial for its antitumor activity, interfering with DNA synthesis. This compound is valuable in antiviral and anticancer drug development due to its optimized pharmacokinetic properties and selective cytotoxicity.