2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

• CAT Number: R066672
• CAS Number: 24967-27-9
• Molecular Formula: C11H17NO8
• Molecular Weight: 291.25
• Purity: ≥95%
• Synonyms: (2R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
• IUPAC Name: (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
• InChI: InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1
• InChIKey: JINJZWSZQKHCIP-UFGQHTETSA-N
• SMILES: CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@@H]([C@@H](CO)O)O)C(=O)O)O

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid (Cat No.:R066672) is a sialic acid analog known for its potent inhibition of sialidases (neuraminidases), enzymes that cleave sialic acid residues from glycoproteins and glycolipids. By mimicking the transition state of sialic acid cleavage, DANA competitively inhibits viral and bacterial neuraminidases, making it a valuable tool in antiviral and antibacterial research. It has been widely used to study sialic acid-related metabolic pathways and host–pathogen interactions. DANA’s broad-spectrum activity and stable structure make it a key reference compound in developing sialidase-targeted therapeutics for infectious and inflammatory diseases.