21-Acetyl-6α-chlorotriamcinolone Acetonide

• CAT Number: R030827
• CAS Number: 1181-32-4
• Molecular Formula: C₂₆H₃₂ClFO₇
• Molecular Weight: 510.98
• Purity: ≥95%
• Synonyms: (6α,11β,16α)-21-(Acetyloxy)-6-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; 6α-Chloro-9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-Acetate Cyclic 16,17-Acetal with Acetone?
• Storage: -20°C
• IUPAC Name: [2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-19-chloro-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] acetate
• InChI: InChI=1S/C26H32ClFO7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
• InChIKey: QKCQMVXAOYYSJU-IUGZLZTKSA-N
• SMILES: CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)C=C[C@@]54C)Cl)F)O)C)OC(O2)(C)C

21-Acetyl-6α-chlorotriamcinolone acetonide(CAT: R030827) is a synthetic corticosteroid derivative known for its enhanced anti-inflammatory and immunosuppressive properties. Structurally, it features a 6α-chloro group, a 21-acetyl ester, and a 16,17-acetonide moiety, which together improve its lipophilicity, receptor binding affinity, and resistance to metabolic degradation. These enhancements contribute to prolonged activity and increased potency in preclinical models. The compound is commonly used in pharmaceutical research to investigate corticosteroid mechanisms and develop new glucocorticoid-based treatments for inflammatory conditions.