2-tert-Butyl-1,1,3,3-tetramethylguanidine

• CAT Number: R014476
• CAS Number: 29166-72-1
• Molecular Formula: C9H21N3
• Molecular Weight: 171.29
• Purity: ≥95%
• Synonyms: Barton base; N-tert-Butyl-N’,N’,N’’,N’’-tetramethylguanidine; Tetramethyl-2-tert-butylguanidine
• Storage: Store at -20C
• IUPAC Name: 2-tert-butyl-1,1,3,3-tetramethylguanidine
• InChI: InChI=1S/C9H21N3/c1-9(2,3)10-8(11(4)5)12(6)7/h1-7H3
• InChIKey: YQHJFPFNGVDEDT-UHFFFAOYSA-N
• SMILES: CC(C)(C)N=C(N(C)C)N(C)C

2-tert-Butyl-1,1,3,3-tetramethylguanidine（Cat No.:R014476）is an organic compound that acts as a strong, non-nucleophilic base. It features a guanidine core with bulky tert-butyl and methyl substituents, enhancing its steric hindrance and stability. This structure makes it a useful base in organic synthesis, particularly in reactions like deprotonation, where a strong base is needed without nucleophilic interference. It is employed in the preparation of enolates, nucleophilic substitutions, and other transformations. Its steric bulk and non-nucleophilic nature make it valuable in selectively promoting certain chemical reactions without unwanted side reactions.