For research use only. Not for therapeutic Use.
(2-Pyridyldithio)-PEG4-alcohol(CAT: I016476) is a heterobifunctional crosslinking reagent containing a thiol-reactive pyridyldithiol group and a terminal hydroxyl group. The pyridyldithiol moiety enables selective disulfide exchange with free thiols, allowing site-specific conjugation to cysteine residues, while the hydroxyl group offers versatility for further derivatization or coupling through esterification, ether formation, or carbamate chemistry. The PEG4 spacer provides aqueous solubility, flexibility, and reduced steric hindrance, facilitating efficient bioconjugation. This reagent is widely applied in protein modification, antibody–drug conjugates (ADCs), probe synthesis, and biomaterials engineering. (2-Pyridyldithio)-PEG4-alcohol is a useful tool for constructing multifunctional molecules with cleavable, thiol-sensitive linkages.
| CAS Number | 851961-99-4 |
| Synonyms | 2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethanol |
| Molecular Formula | C13H21NO4S2 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethanol |
| InChI | InChI=1S/C13H21NO4S2/c15-5-6-16-7-8-17-9-10-18-11-12-19-20-13-3-1-2-4-14-13/h1-4,15H,5-12H2 |
| InChIKey | NVGYTXVKRZYCDH-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)SSCCOCCOCCOCCO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
