(2-Pyridyldithio)-PEG2-Boc

• CAT Number: I016474
• CAS Number: 2144777-73-9
• Molecular Formula: C16H25NO4S2
• Molecular Weight: 359.50
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C16H25NO4S2/c1-16(2,3)21-15(18)7-9-19-10-11-20-12-13-22-23-14-6-4-5-8-17-14/h4-6,8H,7,9-13H2,1-3H3
• InChIKey: NFTUEHOZCVWJPT-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCSSC1=CC=CC=N1

(2-Pyridyldithio)-PEG2-Boc(CAT: I016474) is a heterobifunctional PEG linker designed for selective and efficient bioconjugation. It features a 2-pyridyldithiol group, enabling thiol-reactive disulfide exchange with cysteine residues or sulfhydryl-containing molecules, and a Boc-protected amine that can be deprotected to reveal a primary amine for further coupling. The short PEG2 spacer provides flexibility, improved solubility, and reduced steric hindrance during conjugation. This dual-reactive functionality makes (2-Pyridyldithio)-PEG2-Boc a valuable tool in protein modification, antibody-drug conjugates, and crosslinking applications, supporting research in chemical biology, drug development, and biomaterials engineering.