2-(Methylsulfonyl)ethyl n-succinimidyl carbonate

• CAT Number: R014485
• CAS Number: 57903-15-8
• Molecular Formula: C8H11NO7S
• Molecular Weight: 265.24
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 2-methylsulfonylethyl carbonate
• InChI: InChI=1S/C8H11NO7S/c1-17(13,14)5-4-15-8(12)16-9-6(10)2-3-7(9)11/h2-5H2,1H3
• InChIKey: KSMLVLJMKBLJJL-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)CCOC(=O)ON1C(=O)CCC1=O

2-(Methylsulfonyl)ethyl N-succinimidyl carbonate(CAT: R014485) is a versatile heterobifunctional crosslinking reagent designed for bioconjugation and protein labeling applications. Featuring an NHS carbonate ester and a methylsulfonyl-activated leaving group, it reacts selectively with primary amines on proteins or peptides to form stable carbamate linkages. This reagent not only facilitates targeted protein crosslinking but also serves as a temporary amino-protective group, allowing controlled modification of biomolecules. Its mild reactivity and aqueous solubility make it ideal for applications such as antibody-drug conjugate (ADC) synthesis, PEGylation, and advanced labeling strategies in biochemical assays, proteomics, and therapeutic research.