2-Mesitylenesulfonyl chloride

• CAT Number: L010874
• CAS Number: 773-64-8
• Molecular Formula: C9H11ClO2S
• Molecular Weight: 218.71
• Purity: ≥95%
• IUPAC Name: 2,4,6-trimethylbenzenesulfonyl chloride
• InChI: InChI=1S/C9H11ClO2S/c1-6-4-7(2)9(8(3)5-6)13(10,11)12/h4-5H,1-3H3
• InChIKey: PVJZBZSCGJAWNG-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C(=C1)C)S(=O)(=O)Cl)C

2-Mesitylenesulfonyl chloride(CAT: L010874) is an aromatic sulfonyl chloride featuring a mesitylene (1,3,5-trimethylbenzene) core with a sulfonyl chloride group at the 2-position. This compound is a highly reactive electrophile, commonly used in the synthesis of sulfonamides, sulfonate esters, and heterocycles. Its sterically hindered aromatic ring imparts selectivity and stability, making it particularly useful in protecting group strategies, peptide modifications, and pharmaceutical intermediate synthesis. The electron-donating methyl groups influence reactivity and help stabilize reaction intermediates. 2-Mesitylenesulfonyl chloride is ideal for applications requiring controlled sulfonylation under mild conditions, and it plays a significant role in medicinal chemistry and organic synthesis workflows.