For research use only. Not for therapeutic Use.
2-Hydroxy Atorvastatin Lactone（Cat No.:R004665）is an active oxidative metabolite of atorvastatin, a widely used HMG-CoA reductase inhibitor for cholesterol management. Formed via hepatic metabolism, this lactone derivative retains lipid-lowering activity and contributes to the pharmacological profile of atorvastatin. It is frequently studied in drug metabolism, pharmacokinetics, and toxicology to evaluate statin biotransformation, bioavailability, and safety. Research also explores its potential role in off-target effects, including myopathy risk. 2-Hydroxy Atorvastatin Lactone is a key reference compound in cardiovascular, metabolic, and pharmacological investigations.
| CAS Number | 163217-74-1 |
| Synonyms | 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-phenyl-2-propan-2-ylpyrrole-3-carboxamide |
| Molecular Formula | C33H33FN2O5 |
| Purity | ≥95% |
| IUPAC Name | 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-phenyl-2-propan-2-ylpyrrole-3-carboxamide |
| InChI | InChI=1S/C33H33FN2O5/c1-20(2)31-30(33(40)35-26-10-6-7-11-27(26)38)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-25-18-24(37)19-28(39)41-25/h3-15,20,24-25,37-38H,16-19H2,1-2H3,(H,35,40)/t24-,25-/m1/s1 |
| InChIKey | MNECBMZJZFGTIK-JWQCQUIFSA-N |
| SMILES | CC(C)C1=C(C(=C(N1CC[C@@H]2C[C@H](CC(=O)O2)O)C3=CC=C(C=C3)F)C4=CC=CC=C4)C(=O)NC5=CC=CC=C5O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
