2-Cyanoethyl N,N,N’,N’-Tetraisopropylphosphoramidite

• CAT Number: R000660
• CAS Number: 102691-36-1
• Molecular Formula: C15H32N3OP
• Molecular Weight: 301.42
• Purity: ≥95%
• Synonyms: N,N,N’,N’-Tetrakis(1-methylethyl)phosphorodiamidous Acid 2-Cyanoethyl Ester; 2-Cyanoethoxybis(N,N-diisopropylamino)phosphine; 2-Cyanoethyl Tetraisopropylphosphorodiamidite; Bis(diisopropylamino)(2-cyanoethoxy)phosphine
• Storage: Store at RT
• IUPAC Name: 3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
• InChI: InChI=1S/C15H32N3OP/c1-12(2)17(13(3)4)20(19-11-9-10-16)18(14(5)6)15(7)8/h12-15H,9,11H2,1-8H3
• InChIKey: RKVHNYJPIXOHRW-UHFFFAOYSA-N
• SMILES: CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OCCC#N

2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphoramidite（Cat No.:R000660）is a widely used reagent in oligonucleotide synthesis, particularly in the formation of phosphite triester linkages. Its structure features a reactive phosphoramidite core with four isopropyl groups providing steric protection and a 2-cyanoethyl group that serves as a removable protecting moiety during solid-phase synthesis. This compound enables efficient, high-yield coupling of nucleoside units under mild conditions, making it essential in automated DNA/RNA synthesis. Its controlled reactivity, stability, and compatibility with standard deprotection strategies contribute to its reliability in producing high-purity synthetic oligonucleotides for research and therapeutic applications.