2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde

• CAT Number: R004989
• CAS Number: 83857-96-9
• Molecular Formula: C8H11ClN2O
• Molecular Weight: 186.64
• Purity: ≥95%
• Synonyms: 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde; 2-Butyl-4-chloro?-5-formylimidazole; 2-Butyl-4-chloroimidazole-5-carboxaldehyde; 2-Butyl-5-formyl-4-chloroimidazole
• Storage: 4°C
• IUPAC Name: 2-butyl-5-chloro-1H-imidazole-4-carbaldehyde
• InChI: InChI=1S/C8H11ClN2O/c1-2-3-4-7-10-6(5-12)8(9)11-7/h5H,2-4H2,1H3,(H,10,11)
• InChIKey: JLVIHQCWASNXCK-UHFFFAOYSA-N
• SMILES: CCCCC1=NC(=C(N1)Cl)C=O

2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde(CAT: R004989) is a functionalized imidazole derivative bearing a butyl group at the 2-position, a chlorine atom at the 4-position, and an aldehyde group at the 5-position. This substitution pattern imparts both lipophilic and electrophilic characteristics, making it a versatile intermediate in pharmaceutical synthesis. It is notably employed in the preparation of angiotensin II receptor blockers (ARBs) such as candesartan and telmisartan, which are used in hypertension and cardiovascular disease management. The reactive aldehyde moiety allows for further derivatization, while the imidazole core provides strong biological relevance in drug design and heterocyclic chemistry research.