2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one

• CAT Number: R029530
• CAS Number: 103962-10-3
• Molecular Formula: C9H6BrF3O2
• Molecular Weight: 283.04
• Purity: ≥95%
• Synonyms: 2-Bromo-1-(4-trifluoromethoxyphenyl)ethanone; 2-Bromo-4’-(trifluoromethoxy)acetophenone; 4-(Trifluoromethoxy)phenacyl bromide
• Storage: Desiccate at +4C
• IUPAC Name: 2-bromo-1-[4-(trifluoromethoxy)phenyl]ethanone
• InChI: InChI=1S/C9H6BrF3O2/c10-5-8(14)6-1-3-7(4-2-6)15-9(11,12)13/h1-4H,5H2
• InChIKey: AOAGGWLQIILIIV-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(=O)CBr)OC(F)(F)F

2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one(CAT: R029530) is a halogenated aryl ketone featuring a bromoacetyl moiety and a para-substituted trifluoromethoxyphenyl ring. This compound serves as a versatile intermediate in pharmaceutical and agrochemical synthesis, particularly in the preparation of α-functionalized aryl ketones and heterocyclic scaffolds. The electrophilic bromoacetyl group enables nucleophilic substitution, facilitating the formation of amides, esters, and heterocycles, while the trifluoromethoxy group enhances lipophilicity, metabolic stability, and binding affinity. It is commonly used in medicinal chemistry for lead optimization and structure–activity relationship (SAR) studies targeting enzyme inhibitors and bioactive compounds.