[2’-(Amino-κN)[1,1’-biphenyl]-2-yl-κC][[3,6-dimethoxy-2’,4’,6’-tris(1-methylethyl)[1,1’-biphenyl]-2-

• CAT Number: R036188
• CAS Number: 1536473-72-9
• Molecular Formula: C44H63NO5PPdS-
• Molecular Weight: 855.44
• Purity: ≥95%
• Synonyms: tBuBrettPhos Pd G3; t-​butylBrettPhos Palladacycle Gen.3; Methanesulfonato(2-(di-t-butylphosphino)-3,6-dimethoxy-2’,4’,6’-tri-i-propyl-1,1’-biphenyl)(2’-amino-1,1’-biphenyl-2-yl)palladium(II)
• Storage: Store at RT
• IUPAC Name: ditert-butyl-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane;methanesulfonic acid;palladium;2-phenylaniline
• InChI: InChI=1S/C31H49O2P.C12H10N.CH4O3S.Pd/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h15-21H,1-14H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;-1
• InChIKey: VKLHIPFGYVFUGT-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC(=C(C(=C1)C(C)C)C2=C(C=CC(=C2P(C(C)(C)C)C(C)(C)C)OC)OC)C(C)C.CS(=O)(=O)O.C1=CC=C([C-]=C1)C2=CC=CC=C2N.[Pd]

tBuBrettPhos Pd G3 (CAT: R036188) is a pre-formed, air-stable palladium(0) precatalyst complexed with the bulky, electron-rich tert-butyl-substituted BrettPhos ligand. Designed for high efficiency in cross-coupling reactions, it offers excellent reactivity in C–N, C–O, and C–C bond formation, especially under mild conditions and with sterically hindered or electronically challenging substrates. Its third-generation design improves solubility, stability, and catalyst activation profiles, enabling broad substrate scope and fast reaction times. Widely used in medicinal chemistry and complex molecule synthesis, tBuBrettPhos Pd G3 streamlines catalytic workflows in both academic and industrial labs.