For research use only. Not for therapeutic Use.
(1R,9R)-Exatecan mesylate ((1R,9R)-DX8951f)(CAT: I040331) is a stereoisomer of Exatecan mesylate (HY-13631A), a potent DNA topoisomerase I inhibitor that interferes with DNA replication and transcription by stabilizing the topoisomerase I-DNA cleavage complex. With an IC₅₀ of 2.2 μM (0.975 μg/mL), this compound effectively induces cytotoxicity in proliferating cancer cells. The (1R,9R) configuration may offer unique pharmacokinetic or pharmacodynamic profiles, making it a valuable agent in stereoselective anticancer drug research. (1R,9R)-Exatecan mesylate is widely used in studies involving targeted chemotherapy, DNA damage response, and payload design for antibody-drug conjugates (ADCs).
| CAS Number | 2938875-39-7 |
| Synonyms | (10R,23R)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid |
| Molecular Formula | C25H26FN3O7S |
| Purity | ≥95% |
| IUPAC Name | (10R,23R)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid |
| InChI | InChI=1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H3,(H,2,3,4)/t16-,24-;/m1./s1 |
| InChIKey | BICYDYDJHSBMFS-AKYVXKJQSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O.CS(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
