(1R,2R)-ML-SI3

• CAT Number: I044108
• CAS Number: 2418594-00-8
• Molecular Formula: C23H31N3O3S
• Molecular Weight: 429.58
• Purity: ≥95%
• Synonyms: N-[(1R,2R)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide
• InChI: InChI=1S/C23H31N3O3S/c1-29-23-14-8-7-13-22(23)26-17-15-25(16-18-26)21-12-6-5-11-20(21)24-30(27,28)19-9-3-2-4-10-19/h2-4,7-10,13-14,20-21,24H,5-6,11-12,15-18H2,1H3/t20-,21-/m1/s1
• InChIKey: OVTXOMMQHRIKGL-NHCUHLMSSA-N
• SMILES: COC1=CC=CC=C1N2CCN(CC2)[C@@H]3CCCC[C@H]3NS(=O)(=O)C4=CC=CC=C4

(1R,2R)-ML-SI3（Cat No.:I044108）is a potent and stereoselective inhibitor of Salt-Inducible Kinase 3 (SIK3), a member of the AMPK-related kinase family involved in metabolic regulation, circadian rhythm, and inflammatory signaling. By selectively targeting SIK3, (1R,2R)-ML-SI3 modulates downstream effectors such as HDACs and CRTCs, influencing gene expression and immune cell behavior. It is widely used in immunometabolism and neurobiology research to explore SIK3-specific functions, including its role in macrophage polarization and hypothalamic control of metabolism. This enantiomer-specific compound supports the development of SIK-targeted therapies for metabolic and inflammatory diseases.