18-Oxocortisol

• CAT Number: I045886
• CAS Number: 2410-60-8
• Molecular Formula: C21H28O6
• Molecular Weight: 376.44
• Purity: ≥95%
• Synonyms: (8S,9S,10R,11S,13R,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde
• InChI: InChI=1S/C21H28O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,11,14-16,18,22,25,27H,2-7,9-10H2,1H3/t14-,15-,16-,18+,19-,20+,21-/m0/s1
• InChIKey: XUQWWIFROYJHCU-UKSDXMLSSA-N
• SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C=O)O

18-Oxocortisol（Cat No.:I045886）is an endogenous steroid and oxidized cortisol metabolite belonging to the corticosteroid family. It plays a significant role in adrenal physiology and is considered a biomarker in disorders such as primary aldosteronism and adrenal hyperplasia. Structurally, it retains cortisol’s glucocorticoid framework with an additional keto group at the C-18 position, influencing its biological activity. Researchers employ 18-oxocortisol in endocrinology studies, biomarker validation, and clinical research to investigate adrenal steroidogenesis, diagnostic pathways, and disease mechanisms. It is valuable in exploring hormone regulation and adrenal-related pathologies.