16α-Methyl-9,11-dehydro Prednisolone

• CAT Number: R050590
• CAS Number: 13209-41-1
• Molecular Formula: C22H28O4
• Molecular Weight: 356.46
• Purity: ≥95%
• Synonyms: (16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; 17α,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione; Dexamethasone Impurity E (EP)
• Target: Vitamin D Related/Nuclear Receptor
• Storage: -20°C
• IUPAC Name: (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1
• InChIKey: ZYTXTXAMMDTYDQ-DGEXFFLYSA-N
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC[C@@]2([C@]1(C(=O)CO)O)C)C

16α-Methyl-9,11-dehydro prednisolone（Cat No.:R050590）is a synthetic corticosteroid derivative structurally related to prednisolone, featuring a methyl group at the 16α position and a double bond between the 9 and 11 carbon atoms. These modifications enhance its anti-inflammatory and glucocorticoid activity while reducing mineralocorticoid effects. It is designed to modulate immune responses and reduce inflammation in conditions such as autoimmune disorders, allergic reactions, and certain chronic inflammatory diseases. The compound interacts with glucocorticoid receptors to regulate gene expression, suppress pro-inflammatory cytokines, and modulate metabolic pathways. Its potency allows for effective treatment at lower dosages.