15-Keto Prostaglandin E2 - CAS 26441-05-4

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH. In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).

Catalog Number: R035962

CAS Number: 26441-05-4

PubChem Substance ID:355076675

Molecular Formula: C20H30O5

Molecular Weight:350.455

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms(5Z,11α,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic Acid; 15-Dehydroprostaglandin E2; 7-[3-Hydroxy-5-oxo-2-(3-oxo-1-octenyl)cyclopentyl]-5-heptenoic Acid; 15-Keto PGE2; 15-Ketoprostaglandin E2; 15-Oxo-PGE2; 15-Oxoprostaglandin E2; 15-Keto-PGE2;

Property

Molecular Formula: C20H30O5
Molecular Weight350.455
Purity≥95%
Storage-20°C

Computed Descriptor

IUPAC Name(Z)-7-[(1R,2R,3R)-3-hydroxy-5-oxo-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid
InChIInChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-17,19,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,19-/m1/s1
InChIKeyYRTJDWROBKPZNV-KMXMBPPJSA-N
SMILESCCCCCC(=O)C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O