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(14R)-14-Hydroxyclarithromycin

(14R)-14-Hydroxyclarithromycin

  • CAT Number: R068066
  • CAS Number: 116836-41-0
  • Molecular Formula: C38H69NO14
  • Molecular Weight: 763.95
  • Purity: ≥95%
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(14R)-14-Hydroxyclarithromycin(CAS 116836-41-0), also known asclarithromycin,is a semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms.

Catalog Number R068066
CAS Number 116836-41-0
Molecular Formula

C38H69NO14

Purity 95%
Storage RT
IUPAC Name (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
InChI InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChIKey AGOYDEPGAOXOCK-KCBOHYOISA-N
SMILES CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O
Reference

<span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>1.<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Peters, David H., and Stephen P. Clissold. &quot;Clarithromycin.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Drugs</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;44.1 (1992): 117-164.<br />
2.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Rodvold, Keith A. &quot;Clinical pharmacokinetics of clarithromycin.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Clinical pharmacokinetics</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;37.5 (1999): 385-398.</span></span></span></span>

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