1,4,8,11-Tetraazacyclotetradecane

• CAT Number: R039608
• CAS Number: 295-37-4
• Molecular Formula: C10H24N4
• Molecular Weight: 200.33
• Purity: ≥95%
• Synonyms: Cyclam; JM 1498; NSC 180811
• Storage: Store at +4C
• IUPAC Name: 1,4,8,11-tetrazacyclotetradecane
• InChI: InChI=1S/C10H24N4/c1-3-11-7-9-13-5-2-6-14-10-8-12-4-1/h11-14H,1-10H2
• InChIKey: MDAXKAUIABOHTD-UHFFFAOYSA-N
• SMILES: C1CNCCNCCCNCCNC1

1,4,8,11-Tetraazacyclotetradecane(CAT: R039608), also known as cyclam, is a macrocyclic tetraamine ligand featuring a 14-membered ring with four nitrogen donor atoms. Its strong chelating ability makes it a versatile scaffold in coordination chemistry, particularly for forming stable complexes with transition metals such as copper, nickel, and zinc. Cyclam and its metal complexes are widely studied for applications in catalysis, molecular recognition, MRI contrast agents, and anticancer therapies. Its rigid cyclic structure provides defined geometry and high thermodynamic stability, enabling use in supramolecular assemblies and bioinorganic models. Cyclam is also a key component in the design of metal-based sensors and diagnostics.