1.3-Benzodioxole

• CAT Number: R070113
• CAS Number: 274-09-9
• Molecular Formula: C7H6O2
• Molecular Weight: 122.12
• Purity: ≥95%
• Synonyms: 1.2-Methylenedioxybenzene
• Storage: RT
• IUPAC Name: 1,3-benzodioxole
• InChI: InChI=1S/C7H6O2/c1-2-4-7-6(3-1)8-5-9-7/h1-4H,5H2
• InChIKey: FTNJQNQLEGKTGD-UHFFFAOYSA-N
• SMILES: C1OC2=CC=CC=C2O1

1,3-Benzodioxole(CAT: R070113), also known as methylenedioxybenzene, is a heterocyclic aromatic compound featuring a benzene ring fused with a 1,3-dioxole ring. This simple yet versatile structure is a key scaffold in natural products and synthetic compounds, including pharmaceuticals, agrochemicals, and fragrances. It is commonly found in bioactive molecules such as safrole and piperonyl butoxide. Due to its electron-rich nature, 1,3-benzodioxole participates readily in electrophilic aromatic substitution and oxidative transformations. Its presence enhances lipophilicity and metabolic stability, making it a valuable building block in medicinal chemistry, flavor and fragrance design, and the development of advanced organic materials.