12-Ketodeoxycholic acid

• CAT Number: I015505
• CAS Number: 5130-29-0
• Molecular Formula: C24H38O4
• Molecular Weight: 390.56
• Purity: ≥95%
• Synonyms: (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
• InChI: InChI=1S/C24H38O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,23+,24-/m1/s1
• InChIKey: CVNYHSDFZXHMMJ-VPUMZWJWSA-N
• SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(C(=O)C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C

12-Ketodeoxycholic acid（Cat No.:I015505）is a secondary bile acid derivative formed through microbial or metabolic oxidation of deoxycholic acid. It plays a role in bile acid metabolism and signaling, influencing lipid absorption, cholesterol homeostasis, and gut microbiota interactions. Researchers use it to investigate nuclear receptors such as FXR and TGR5, which regulate glucose, lipid, and energy metabolism. Its altered levels have been linked to liver diseases, gastrointestinal disorders, and metabolic syndromes. 12-Ketodeoxycholic acid serves as a valuable biochemical tool in hepatology, endocrinology, and gastrointestinal research.